Quality evaluation of human and environmental toxicity studies performed with nanomaterials – the GUIDEnano approach

The European Union FP-7 project GUIDEnano developed a web-based guidance tool, which guides users to assess human and environmental risks of nanomaterial-enabled products throughout their life cycle. One of the aims in the GUIDEnano hazard assessment strategy is to derive safety limit values based on existing human toxicity and ecotoxicological Read more…

Development of a systematic method to assess similarity between nanomaterials for human hazard evaluation purposes – lessons learnt

Within the EU FP-7 GUIDEnano project, a methodology was developed to systematically quantify the similarity between a nanomaterial (NM) that has been tested in toxicity studies and the NM for which risk needs to be evaluated, for the purpose of extrapolating toxicity data between the two materials. The methodology is Read more…

Contribution of M-cells and other experimental variables in the translocation of TiO2 nanoparticles across in vitro intestinal models

The prediction of nanomaterial (NM) intestinal absorption is a key step in the evaluation of risks after oral exposure. The Caco-2 monolayer model is widely used to predict the permeability of substances across the intestinal barrier. The addition of M-cells should improve the relevance of the model for NMs, since Read more…