Toxicology

The HEHS Center has capacities to characterize the human health hazard of chemical substances (including nanomaterials) through in vitro and in vivo tests.

In Vitro Toxicology & In Vitro Biokinetics

Characterization of the in vitro toxicological profile in a range of different assays and human cell lines

  • Dissolution test in different biological media
  • Particle surface reactivity
  • Viability, proliferation and apoptosis
  • Oxidative stress & Inflammatory responses
  • Phagocytic activity and frustrated phagocytosis
  • Phototoxicity
  • Genotoxicity/Photogenotoxicity
  • Membrane integrity
  • Cell uptake and intracellular trafficking
  • Intestinal barrier permeability
  • Particle tracking and characterization in biological matrices (TEM, SEM, confocal microscopy, ICP-MS, etc)
Toxicology and Biokinetics in Rodents

Characterization of the in vivo toxicity and biokinetic profile by different routes of administration such as oral, dermal or parenteral tested on mice and rats. We perform OECD-like evaluations with a nanospecific focus.

  • Clinical signs of toxicity
  • Body weight
  • Gross pathology and organ weight
  • Histopathology
  • Hematology & Blood chemistry
  • Inflammatory markers
  • Genotoxicity
  • Gut microbiota
  • Particle tracking and characterization in biological matrices